The field for the 148th running of the Kentucky Derby is set. The 2022 Run for the Roses features several strong horses but no runaway favorite. This race may be wide open.
| Post | Horse | Jockey | Trainer | Odds* |
| 1 | Mo Donegal | Irad Ortiz Jr. | Todd Pletcher | 9-1 |
| 2 | Happy Jack | Rafael Bejarano | Doug O’Neill | 20-1 |
| 3 | Epicenter | Joel Rosario | Steve Asmussen | 5-1 |
| 4 | Summer Is Tomorrow | Mickael Barzalona | Bhupat Seemar | 32-1 |
| 5 | Smile Happy | Corey Lanerie | Kenny McPeek | 15-1 |
| 6 | Messier | John Velazquez | Tim Yakteen | 6-1 |
| 7 | Crown Pride | Christophe Lemaire | Koichi Shintani | 17-1 |
| 8 | Charge It | Luis Saez | Todd Pletcher | 14-1 |
| 9 | Tiz the Bomb | Brian Hernandez Jr. | Kenny McPeek | 26-1 |
| 10 | Zandon | Flavien Prat | Chad Brown | 7-1 |
| 11 | Pioneer of Medina | Joe Bravo | Todd Pletcher | 50-1 |
| 12 | Taiba | Mike Smith | Tim Yakteen | 5-1 |
| 13 | Simplification | Jose Ortiz | Antonio Sano | 37-1 |
| 14 | Barber Road | Reylu Gutierrez | John Ortiz | 50-1 |
| 15 | White Abarrio | Tyler Gaffalione | Saffie Joseph Jr. | 13-1 |
| 16 | Cyberknife | Florent Geroux | Brad Cox | 12-1 |
| 17 | Classic Causeway | Julien Leparoux | Brian Lynch | 76-1 |
| 18 | Tawny Port | Ricardo Santana Jr. | Brad Cox | 76-1 |
| 19 | Zozos | Manny Franco | Brad Cox | 44-1 |
| 20 | Ethereal Road | Luis Contreros | D. Wayne Lukas | Scratched |
| 21 | Rich Strike | Sonny Leon | Eric Reed | 93-1 |
| 22 | Rattle N Roll | James Graham | Kenny McPeek | Scratched |
The early favorite was Zandon but as the race gets closer that looks to be changing.
Several trainers have multiple horses running in 2022. Todd Pletcher has 3. Brad Cox has 3. One of the big stories this year is not about who’s at the Derby this year but who’s NOT at the Derby this year. Trainer Bob Baffert has no entries due to a suspension after last year’s disqualification of Medina Spirit.